Anticonvulsants and Chromatin-Genes Expression: A Systems Biology Investigation
نویسندگان
چکیده
منابع مشابه
Systems biology meets chromatin function
Introduction It is clear that DNA sequence and transcription factor availability alone are not sufficient for effective gene regulation in eukaryotes. Epigenetic factors at various levels also have an essential role: for example, DNA methylation and histone modifications form the molecular basis of gene regulation by creating chromatin microenvironments that promote or prevent transcription. Ge...
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Integrative Systems Biology Investigation of Fabry Disease
Fabry disease (FD) is a rare X-linked recessive genetic disorder caused by a deficient activity of the lysosomal enzyme alpha-galactosidase A (GLA) and is characterised by intra-lysosomal accumulation of globotriaosylceramide (Gb3). We performed a meta-analysis of peer-reviewed publications including high-throughput omics technologies including naïve patients and those undergoing enzyme replace...
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ژورنال
عنوان ژورنال: Frontiers in Neuroscience
سال: 2020
ISSN: 1662-453X
DOI: 10.3389/fnins.2020.591196